Stroke-Induced Immunodepression Is a Marker of Severe Brain Damage

To the Editor:In the last years, several groups, including ours, have described the main traits and clinical implications of a stroke-induced immunodepression syndrome.1,2 This syndrome has raised the attention of the scientific community because it opens a field to assay newer diagnostic and therapeutic avenues for stroke. In a recent article in Stroke ,3 Hug et al confirm many of the descriptions made in previous works and conclude that the main determinant of the immune changes that follow stroke and of the risk of stroke-associated infection is infarct volume. Indeed, this conclusion is reassuring because we have repeatedly described that stroke-associated infection is a marker of the severity of the disease.4,5 We have shown that some …