Baroreflex: A New Therapeutic Target in Human Stroke? | Zendy

M. Sýkora | Zendy; Jennifer Diedler | Zendy; Peter Turčáni | Zendy; Werner Hacke | Zendy; Thorsten Steiner | Zendy

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Baroreflex: A New Therapeutic Target in Human Stroke?

Author(s) -

M. Sýkora,

Jennifer Diedler,

Peter Turčáni,

Werner Hacke,

Thorsten Steiner

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.565838

Subject(s) - medicine , baroreflex , stroke (engine) , pathophysiology , cardiology , anesthesia , blood pressure , heart rate , mechanical engineering , engineering

Autonomic dysfunction, including increased sympathetic drive and blunted baroreflex, has repeatedly been observed in acute stroke. Of clinical importance is that the stroke-related autonomic imbalance seems to be linked to worse outcome after stroke. Here, we discuss the role of baroreflex impairment in acute stroke and its possible pathophysiological and therapeutic relevance. Summary of Review- Possible mechanisms linking baroreflex impairment with unfavorable outcome in stroke may include increased cardiovascular morbidity and mortality, promotion of secondary brain injury due to local inflammation, hyperglycemia, or altered cerebral perfusion.

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