Open AccessAnalysis of Genetic Variability and Whole Genome Linkage of Whole-Brain, Subcortical, and Ependymal Hyperintense White Matter Volume
Author(s) -
Peter Kochunov,
David C. Glahn,
Anderson M. Winkler,
Ravindranath Duggirala,
Rene L. Olvera,
Shelley A. Cole,
Thomas D. Dyer,
Laura Almasy,
Peter T. Fox,
John Blangero
Publication year - 2009
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.109.565390
Subject(s) - heritability , white matter , brain size , medicine , leukoaraiosis , genetic linkage , neuroimaging , population , biology , genetics , magnetic resonance imaging , gene , psychiatry , environmental health , radiology
The cerebral volume of T2-hyperintense white matter (HWM) is an important neuroimaging marker of cerebral integrity. Pathophysiology studies identified that subcortical and ependymal HWM are produced by 2 different mechanisms but shared a common risk factor: high arterial pulse pressure. Recent studies have demonstrated high heritability of the whole-brain HMW volume and reported significant and suggestive evidence of genetic linkage. We performed heritability and whole-genome linkage analysis to replicate previous reported findings and to study shared genetic variance, and possible overlap for specific loci, between subcortical and ependymal HWM volumes in a population of healthy Mexican Americans.
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