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Ancrod in Acute Ischemic Stroke
Author(s) -
David E. Levy,
Gregory J. del Zoppo,
Bart M. Demaerschalk,
Andrew M. Demchuk,
HansChristoph Diener,
George Howard,
Markku Kaste,
Arthur Pancioli,
E. Bernd Ringelstein,
Carmen Spatareanu,
Warren W. Wasiewski
Publication year - 2009
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.109.565119
Subject(s) - medicine , placebo , modified rankin scale , stroke (engine) , dosing , interim analysis , surgery , anesthesia , clinical trial , ischemic stroke , ischemia , mechanical engineering , alternative medicine , pathology , engineering
Previous studies of multiple-day dosing with the defibrinogenating agent, ancrod, in acute ischemic stroke yielded conflicting results but suggested that a brief dosing regimen might improve efficacy and safety. The Ancrod Stroke Program was designed to test this concept in subjects beginning ancrod or placebo within 6 hours of the onset of acute ischemic stroke.

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