Vascular Endothelial Growth Factor Receptor-2 Inhibition Promotes Cell Death and Limits Endothelial Cell Proliferation in a Neonatal Rodent Model of Stroke | Zendy

Janet Shimotake | Zendy; Nikita Derugin | Zendy; Michael F. Wendland | Zendy; Zinaida S. Vexler | Zendy; Donna M. Ferriero | Zendy

Open Access

Vascular Endothelial Growth Factor Receptor-2 Inhibition Promotes Cell Death and Limits Endothelial Cell Proliferation in a Neonatal Rodent Model of Stroke

Author(s) -

Janet Shimotake,

Nikita Derugin,

Michael F. Wendland,

Zinaida S. Vexler,

Donna M. Ferriero

Publication year - 2010

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.564229

Subject(s) - medicine , vascular endothelial growth factor , angiogenesis , kinase insert domain receptor , glial fibrillary acidic protein , gliosis , endothelial stem cell , endocrinology , vascular endothelial growth factor a , pathology , biology , immunohistochemistry , in vitro , biochemistry , vegf receptors

Recent studies in neonatal rodent stroke models suggest that recovery is due in part to upregulation of hypoxia-inducible factor-1-a and its downstream target, vascular endothelial growth factor. Vascular endothelial growth factor is upregulated after a hypoxic insult and is involved in neuronal survival, angiogenesis, and neurogenesis during the recovery process.

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