Roles of Inflammation and the Activated Protein C Pathway in the Brain Edema Associated With Cerebral Venous Sinus Thrombosis | Zendy

Mutsumi Nagai | Zendy; Satoshi Terao | Zendy; Gökhan Yılmaz | Zendy; Cigdem Erkuran Yilmaz | Zendy; Charles T. Esmon | Zendy; Eiju Watanabe | Zendy; D. Neil Granger | Zendy

Open Access

Roles of Inflammation and the Activated Protein C Pathway in the Brain Edema Associated With Cerebral Venous Sinus Thrombosis

Author(s) -

Mutsumi Nagai,

Satoshi Terao,

Gökhan Yılmaz,

Cigdem Erkuran Yilmaz,

Charles T. Esmon,

Eiju Watanabe,

D. Neil Granger

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.562983

Subject(s) - medicine , inflammation , protein c , thrombosis , cerebral edema , cerebral venous sinus thrombosis , brain edema , edema , intracranial thrombosis , venous thrombosis , cardiology , stroke (engine) , cerebral veins , pathology , mechanical engineering , engineering

Increased blood-brain barrier (BBB) permeability, brain edema, and hemorrhage are important consequences of cerebral venous sinus thrombosis (CVST). The objective of this study was to define the role of the protein C pathway in the BBB permeability and edema elicited by experimental CVST. The role of neutrophil recruitment was also evaluated.

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