Open AccessSex-Specific Role of Thioredoxin in Neuroprotection Against Iron-Induced Brain Injury Conferred by Estradiol
Author(s) -
Tzu-Yin Chen,
Ke-Li Tsai,
Tzu-Ying Lee,
Chuang C. Chiueh,
WenSen Lee,
Chin Hsu
Publication year - 2009
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.109.562850
Subject(s) - neuroprotection , medicine , stroke (engine) , pharmacology , neuroscience , mechanical engineering , engineering , biology
Accumulation of iron after intracerebral hemorrhage causes free radical formation and oxidative damage resulting in liquefaction. The aim of this study was the investigation of molecular mechanisms underlying estrogen-mediated neuroprotective effect against iron-induced brain injury in vivo.
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