Sonic Hedgehog Regulates Ischemia/Hypoxia-Induced Neural Progenitor Proliferation | Zendy

John R. Sims | Zendy; SaeWon Lee | Zendy; Kamil Topalkara | Zendy; Jianhua Qiu | Zendy; Jian Xu | Zendy; Zhipeng Zhou | Zendy; Michael A. Moskowitz | Zendy

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Sonic Hedgehog Regulates Ischemia/Hypoxia-Induced Neural Progenitor Proliferation

Author(s) -

John R. Sims,

SaeWon Lee,

Kamil Topalkara,

Jianhua Qiu,

Jian Xu,

Zhipeng Zhou,

Michael A. Moskowitz

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.561951

Subject(s) - cyclopamine , sonic hedgehog , progenitor cell , hippocampal formation , hedgehog signaling pathway , microbiology and biotechnology , neural stem cell , hypoxia (environmental) , ischemia , medicine , bromodeoxyuridine , gli1 , endocrinology , biology , stem cell , signal transduction , immunohistochemistry , chemistry , organic chemistry , oxygen

Sonic hedgehog (Shh) protein is required for the maintenance of neural progenitor cells (NPCs) in the embryonic and adult hippocampus. Brain ischemia causes increased proliferation of hippocampal NPCs. We therefore examined whether Shh regulates the increase in proliferation of NPCs after ischemia/hypoxia.

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