Neuroprotection Against Hypoxic-Ischemic Brain Injury by Inhibiting the Apoptotic Protease Activating Factor-1 Pathway | Zendy

Yanqin Gao | Zendy; Peiying Li | Zendy; Xiaoming Hu | Zendy; Wenting Zhang | Zendy; R. Anne Stetler | Zendy; Peter S. Vosler | Zendy; Guodong Cao | Zendy; Jun Chen | Zendy

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Neuroprotection Against Hypoxic-Ischemic Brain Injury by Inhibiting the Apoptotic Protease Activating Factor-1 Pathway

Author(s) -

Yanqin Gao,

Peiying Li,

Xiaoming Hu,

Wenting Zhang,

R. Anne Stetler,

Peter S. Vosler,

Guodong Cao,

Jun Chen

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.561852

Subject(s) - neuroprotection , medicine , apoptosis , pharmacology , protease , stroke (engine) , hypoxia (environmental) , ischemia , enzyme , biochemistry , mechanical engineering , chemistry , organic chemistry , oxygen , engineering

Emerging evidence suggests that mitochondrial damage-mediated neuronal apoptosis is a major contributor to neonatal hypoxic-ischemic (H-I) brain injury. This study was performed to determine whether targeted inhibition of the apoptotic protease activating factor-1 (Apaf-1) signaling pathway downstream of mitochondrial damage confers neuroprotection in rodent models of neonatal H-I.

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