Hypoxic Preconditioning-Induced Cerebral Ischemic Tolerance | Zendy

Bradley K. Wacker | Zendy; Tae Sung Park | Zendy; Jeffrey M. Gidday | Zendy

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Hypoxic Preconditioning-Induced Cerebral Ischemic Tolerance

Author(s) -

Bradley K. Wacker,

Tae Sung Park,

Jeffrey M. Gidday

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.560714

Subject(s) - sphingosine 1 phosphate , medicine , sphingosine , ischemia , sphingosine kinase , hypoxia (environmental) , pharmacology , stroke (engine) , lipid signaling , ischemic preconditioning , endocrinology , chemistry , receptor , mechanical engineering , organic chemistry , oxygen , engineering

The importance of bioactive lipid signaling under physiological and pathophysiological conditions is progressively becoming recognized. The disparate distribution of sphingosine kinase (SphK) isoform activity in normal and ischemic brain, particularly the large excess of SphK2 in cerebral microvascular endothelial cells, suggests potentially unique cell- and region-specific signaling by its product sphingosine-1-phosphate. The present study sought to test the isoform-specific role of SphK as a trigger of hypoxic preconditioning (HPC)-induced ischemic tolerance.

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