Induced Spreading Depression Evokes Cell Division of Astrocytes in the Subpial Zone, Generating Neural Precursor-Like Cells and New Immature Neurons in the Adult Cerebral Cortex | Zendy

Jing-Hui Xue | Zendy; Hiroji Yanamoto | Zendy; Yukako Nakajo | Zendy; Norimitsu Tohnai | Zendy; Yoshikazu Nakano | Zendy; Takuya Hori | Zendy; Koji Iihara | Zendy; Susumu Miyamoto | Zendy

Open Access

Induced Spreading Depression Evokes Cell Division of Astrocytes in the Subpial Zone, Generating Neural Precursor-Like Cells and New Immature Neurons in the Adult Cerebral Cortex

Author(s) -

Jing-Hui Xue,

Hiroji Yanamoto,

Yukako Nakajo,

Norimitsu Tohnai,

Yoshikazu Nakano,

Takuya Hori,

Koji Iihara,

Susumu Miyamoto

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.560334

Subject(s) - nestin , neural stem cell , neuroscience , cerebral cortex , vimentin , biology , cortical spreading depression , progenitor cell , precursor cell , microbiology and biotechnology , pathology , stem cell , immunohistochemistry , medicine , cell , immunology , genetics , migraine

New immature neurons appear out of the germinative zone, in cortical Layers V to VI, after induced spreading depression in the adult rat brain. Because neural progenitors have been isolated in the cortex, we set out to determine whether a subgroup of mature cells in the adult cortex has the potential to divide and generate neural precursors.

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