Relation of Candidate Genes that Encode for Endothelial Function to Migraine and Stroke | Zendy

Leah R. MacClellan | Zendy; Timothy D. Howard | Zendy; John W. Cole | Zendy; O. Colin Stine | Zendy; Wayne H. Giles | Zendy; Jeffery R. O’Connell | Zendy; Marcella A. Wozniak | Zendy; Barney J. Stern | Zendy; Braxton D. Mitchell | Zendy; Steven J. Kittner | Zendy

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Relation of Candidate Genes that Encode for Endothelial Function to Migraine and Stroke

Author(s) -

Leah R. MacClellan,

Timothy D. Howard,

John W. Cole,

O. Colin Stine,

Wayne H. Giles,

Jeffery R. O’Connell,

Marcella A. Wozniak,

Barney J. Stern,

Braxton D. Mitchell,

Steven J. Kittner

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.557462

Subject(s) - migraine , medicine , stroke (engine) , migraine with aura , snp , population , familial hemiplegic migraine , aura , single nucleotide polymorphism , candidate gene , bioinformatics , genetics , gene , genotype , biology , mechanical engineering , environmental health , engineering

Migraine with aura is a risk factor for ischemic stroke, but the mechanism by which these disorders are associated remains unclear. Both disorders exhibit familial clustering, which may imply a genetic influence on migraine and stroke risk. Genes encoding for endothelial function are promising candidate genes for migraine and stroke susceptibility because of the importance of endothelial function in regulating vascular tone and cerebral blood flow.

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