Association of Plasma ADMA Levels With MRI Markers of Vascular Brain Injury | Zendy

Aleksandra Pikula | Zendy; Rainer H. Böger | Zendy; Alexa S. Beiser | Zendy; Renke Maas | Zendy; Charles DeCarli | Zendy; Edzard Schwedhelm | Zendy; Jayandra J. Himali | Zendy; Friedrich Schulze | Zendy; Rhoda Au | Zendy; Margaret KellyHayes | Zendy; Carlos S. Kase | Zendy; Ramachandran S. Vasan | Zendy; Philip A. Wolf | Zendy; Sudha Seshadri | Zendy

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Association of Plasma ADMA Levels With MRI Markers of Vascular Brain Injury

Author(s) -

Aleksandra Pikula,

Rainer H. Böger,

Alexa S. Beiser,

Renke Maas,

Charles DeCarli,

Edzard Schwedhelm,

Jayandra J. Himali,

Friedrich Schulze,

Rhoda Au,

Margaret KellyHayes,

Carlos S. Kase,

Ramachandran S. Vasan,

Philip A. Wolf,

Sudha Seshadri

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.557116

Subject(s) - medicine , subclinical infection , hyperintensity , cardiology , magnetic resonance imaging , asymmetric dimethylarginine , stroke (engine) , endothelial dysfunction , quartile , odds ratio , radiology , confidence interval , arginine , mechanical engineering , biochemistry , chemistry , amino acid , engineering

Asymmetrical dimethylarginine (ADMA), an inhibitor of endothelial nitric oxide synthase, is a marker of endothelial dysfunction. Elevated circulating ADMA concentrations have been associated with systemic and carotid atherosclerosis, an elevated risk of developing stroke, and magnetic resonance imaging white-matter hyperintensities (WMHs). The relation of plasma ADMA to subclinical vascular brain injury has not been previously studied in a middle-aged, community-based sample.

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