Multi-Ethnic Genetic Association Study of Carotid Intima-Media Thickness Using a Targeted Cardiovascular SNP Microarray | Zendy

Matthew B. Lanktree | Zendy; Robert A. Hegele | Zendy; Salim Yusuf | Zendy; Sonia S. Anand | Zendy

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Multi-Ethnic Genetic Association Study of Carotid Intima-Media Thickness Using a Targeted Cardiovascular SNP Microarray

Author(s) -

Matthew B. Lanktree,

Robert A. Hegele,

Salim Yusuf,

Sonia S. Anand

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.556563

Subject(s) - medicine , intima media thickness , snp , single nucleotide polymorphism , genetic association , population , candidate gene , bioinformatics , oncology , genetics , genotype , gene , biology , carotid arteries , environmental health

Identification of subclinical atherosclerosis by ultrasonographic measurement of carotid intima-media thickness (IMT) is a validated tool, in conjunction with traditional risk factors, for clinical assessment of cardiovascular disease risk. IMT has also been recognized as a quantitative measure of cardiovascular disease progression in asymptomatic individuals, and many candidate gene association studies have attempted to identify genetic variants associated with interindividual differences in IMT with limited success. We sought to test the association between subclinical atherosclerosis measured by IMT and approximately 50,000 SNPs, densely mapping approximately 2100 genes found on the gene-centric Illumina cardiovascular disease beadchip in a multi-ethnic population-based sample.

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