Red Blood Cell Transfusion Increases Cerebral Oxygen Delivery in Anemic Patients With Subarachnoid Hemorrhage | Zendy

Rajat Dhar | Zendy; Allyson R. Zazulia | Zendy; Tom O. Videen | Zendy; Gregory J. Zipfel | Zendy; Colin P. Derdeyn | Zendy; Michael N. Diringer | Zendy

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Red Blood Cell Transfusion Increases Cerebral Oxygen Delivery in Anemic Patients With Subarachnoid Hemorrhage

Author(s) -

Rajat Dhar,

Allyson R. Zazulia,

Tom O. Videen,

Gregory J. Zipfel,

Colin P. Derdeyn,

Michael N. Diringer

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.556159

Subject(s) - medicine , subarachnoid hemorrhage , hemoglobin , anesthesia , cerebral blood flow , anemia , ischemia , oxygen , vasospasm , red blood cell , blood transfusion , chemistry , organic chemistry

Anemia is common after subarachnoid hemorrhage and may exacerbate the reduction in oxygen delivery (DO(2)) underlying delayed cerebral ischemia. The association between lower hemoglobin and worse outcome, including more cerebral infarcts, supports a role for red blood cell transfusion to correct anemia. However, the cerebral response to transfusion remains uncertain, because higher hemoglobin may increase viscosity and further impair cerebral blood flow (CBF) in the setting of vasospasm.

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