Robust Docosahexaenoic Acid–Mediated Neuroprotection in a Rat Model of Transient, Focal Cerebral Ischemia | Zendy

Ludmila Belayev | Zendy; Larissa Khoutorova | Zendy; Kristal D. Atkins | Zendy; Nicolás G. Bazán | Zendy

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Robust Docosahexaenoic Acid–Mediated Neuroprotection in a Rat Model of Transient, Focal Cerebral Ischemia

Author(s) -

Ludmila Belayev,

Larissa Khoutorova,

Kristal D. Atkins,

Nicolás G. Bazán

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.555979

Subject(s) - medicine , neuroprotection , docosahexaenoic acid , anesthesia , saline , ischemia , isoflurane , pharmacology , polyunsaturated fatty acid , fatty acid , biochemistry , chemistry

Docosahexaenoic acid (DHA; 22:6n-3), an omega-3 essential fatty acid family member, is the precursor of neuroprotectin D1, which downregulates apoptosis and, in turn, promotes cell survival. This study was conducted to assess whether DHA would show neuroprotective efficacy when systemically administered in different doses after middle cerebral artery occlusion (MCAo) in rats.

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