Apolipoprotein E Genotype Is Related to Progression of White Matter Lesion Load | Zendy

O. Godin | Zendy; Christophe Tzourio | Zendy; Pauline Maillard | Zendy; Annick Alpérovitch | Zendy; Bernard Mazoyer | Zendy; Carole Dufouil | Zendy

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Apolipoprotein E Genotype Is Related to Progression of White Matter Lesion Load

Author(s) -

O. Godin,

Christophe Tzourio,

Pauline Maillard,

Annick Alpérovitch,

Bernard Mazoyer,

Carole Dufouil

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.555839

Subject(s) - medicine , apolipoprotein e , hyperintensity , genotype , apolipoprotein b , population , dementia , cardiology , gastroenterology , cholesterol , disease , genetics , magnetic resonance imaging , radiology , biology , environmental health , gene

The relationship between white matter lesions (WMLs) and the apolipoprotein E genotype has been controversial from cross-sectional studies and no longitudinal finding has been reported. We investigated whether the apolipoprotein E genotype influences baseline and evolution over 4-year follow-up of WML volumes in a population-based sample of 1779 nondemented subjects aged 65 to 80 years old at enrollment.

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