Cryptogenic Stroke: Cryptic Definition?

To the Editor:We have read with great interest the article entitled “May-Turner Syndrome in patients with cryptogenic stroke and patent foramen ovale” which appeared in Stroke .1The article is innovative, being the first large-scale analysis of the association between May-Turner Syndrome, cryptogenic stroke, and patent foramen ovale (PFO). Nonetheless, it arises some uncertainties concerning the definition of “cryptogenic stroke”. In the present study, cryptogenic stroke was defined as “a sudden focal neurological event in the absence of an identifiable cause such as uncontrolled hypertension, intracranial hemorrhage, ipsilateral carotid lesion, atrial fibrillation, intracardiac …