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To the Editor:Serena et al1 are to be congratulated on a comprehensively and carefully conducted trial of the incidence of stroke recurrence in cryptogenic stroke patients with and without patent foramen ovale (PFO). The study showed equal recurrent stroke rates at 2-years follow-up (≈6% in each group).Unfortunately, however, the conclusion they draw from their study, that patent foramen ovale is not a risk factor …

Cryptogenic Stroke and Patent Foramen Ovale: Matched Cohorts in Observational Studies Remain Matched