Efficacy and Safety of Tissue Plasminogen Activator 3 to 4.5 Hours After Acute Ischemic Stroke | Zendy

Maarten G. Lansberg | Zendy; Erich Bluhmki | Zendy; Vincent Thijs | Zendy

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Efficacy and Safety of Tissue Plasminogen Activator 3 to 4.5 Hours After Acute Ischemic Stroke

Author(s) -

Maarten G. Lansberg,

Erich Bluhmki,

Vincent Thijs

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.552547

Subject(s) - medicine , thrombolysis , tissue plasminogen activator , odds ratio , stroke (engine) , placebo , acute stroke , fibrinolytic agent , surgery , myocardial infarction , pathology , mechanical engineering , alternative medicine , engineering

The Third European Cooperative Acute Stroke Study (ECASS-3) demonstrated a benefit of treatment with intravenous tissue plasminogen activator (tPA) for acute stroke in the 3- to 4.5-hour time-window. Prior studies, however, have failed to demonstrate a significant benefit of tPA for patients treated beyond 3 hours. The purpose of this study was to produce reliable and precise estimates of the treatment effect of tPA by pooling data from all relevant studies.

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