Association of the Endogenous Nitric Oxide Synthase Inhibitor ADMA With Carotid Artery Intimal Media Thickness in the Framingham Heart Study Offspring Cohort | Zendy

Renke Maas | Zendy; Vanessa Xanthakis | Zendy; Joseph F. Polak | Zendy; Edzard Schwedhelm | Zendy; Lisa Sullivan | Zendy; Ralf A. Benndorf | Zendy; Friedrich Schulze | Zendy; Ramachandran S. Vasan | Zendy; Philip A. Wolf | Zendy; Rainer H. Böger | Zendy; Sudha Seshadri | Zendy

Open Access

Association of the Endogenous Nitric Oxide Synthase Inhibitor ADMA With Carotid Artery Intimal Media Thickness in the Framingham Heart Study Offspring Cohort

Author(s) -

Renke Maas,

Vanessa Xanthakis,

Joseph F. Polak,

Edzard Schwedhelm,

Lisa Sullivan,

Ralf A. Benndorf,

Friedrich Schulze,

Ramachandran S. Vasan,

Philip A. Wolf,

Rainer H. Böger,

Sudha Seshadri

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.552539

Subject(s) - medicine , cardiology , intima media thickness , asymmetric dimethylarginine , framingham risk score , blood pressure , diabetes mellitus , subclinical infection , endocrinology , carotid arteries , disease , biochemistry , chemistry , amino acid , arginine

Higher plasma concentrations of the endogenous nitric oxides synthase inhibitor asymmetrical dimethylarginine (ADMA) are associated with increased risk of cardiovascular and cerebrovascular events and death, presumably by promoting endothelial dysfunction and subclinical atherosclerosis. We hypothesized that plasma ADMA concentrations are positively related to common carotid artery intimal-media thickness (CCA-IMT) and to internal carotid (ICA)/bulb IMT.

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