Neuroprotective Effects of Leptin and Nitric Oxide Against Cerebral Ischemia | Zendy

Kazushi Tsuda | Zendy

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Neuroprotective Effects of Leptin and Nitric Oxide Against Cerebral Ischemia

Author(s) -

Kazushi Tsuda

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.549402

Subject(s) - neuroprotection , leptin , medicine , nitric oxide , ischemia , nitric oxide synthase , endocrinology , stroke (engine) , pharmacology , mechanical engineering , engineering , obesity

To the Editor:We read with great interest the article by Dr Valerio and colleagues1 dealing with the neuroprotective effect of leptin against ischemic stroke in mice. The results of their study demonstrated that leptin counteracted oxygen-glucose deprivation–induced neuronal apoptosis through signals converting on glycogen synthase kinase-3β (GSK3β) inhibition. The authors also indicated that nuclear factor κB (NF-κB) subunit c-Rel was necessary to leptin-mediated Bcl-xL induction and neuroprotection. In addition, it was shown that leptin mRNA and protein were upregulated after ischemic stroke, …

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