Preliminary Evidence That Ketamine Inhibits Spreading Depolarizations in Acute Human Brain Injury | Zendy

Oliver Sakowitz | Zendy; Karl Kiening | Zendy; Kara Krajewski | Zendy; Asita Sarrafzadeh | Zendy; Martin Fabricius | Zendy; Anthony J. Strong | Zendy; Andreas Unterberg | Zendy; Jens P. Dreier | Zendy

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Preliminary Evidence That Ketamine Inhibits Spreading Depolarizations in Acute Human Brain Injury

Author(s) -

Oliver Sakowitz,

Karl Kiening,

Kara Krajewski,

Asita Sarrafzadeh,

Martin Fabricius,

Anthony J. Strong,

Andreas Unterberg,

Jens P. Dreier

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.109.549303

Subject(s) - medicine , electrocorticography , cortical spreading depression , ketamine , neuroprotection , nmda receptor , antagonist , anesthesia , traumatic brain injury , neuroscience , inhibitory postsynaptic potential , pharmacology , receptor , electroencephalography , psychiatry , biology , migraine

Spreading depolarizations, characterized by large propagating, slow potential changes, have been demonstrated with electrocorticography in patients with cerebral hemorrhage and ischemic stroke. Whereas spreading depolarizations are harmless under normal conditions in animals, they cause or augment damage in the ischemic brain. A fraction of spreading depolarizations is abolished by N-methyl-d-aspartate receptor antagonists. Summary of Case- In 2 patients with severe acute brain injury (traumatic and spontaneous intracranial hemorrhage), spreading depolarizations were inhibited by the noncompetitive N-methyl-d-aspartate receptor antagonist ketamine. This restored electrocorticographic activity.

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