Oxidative-Nitrosative Stress in a Rabbit Pup Model of Germinal Matrix Hemorrhage | Zendy

Muhammad Zia | Zendy; Anna Csiszár | Zendy; Nazar Labinskyy | Zendy; Furong Hu | Zendy; Govindaiah Vinukonda | Zendy; Edmund F. LaGamma | Zendy; Zoltán Ungvári | Zendy; Praveen Ballabh | Zendy

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Oxidative-Nitrosative Stress in a Rabbit Pup Model of Germinal Matrix Hemorrhage

Author(s) -

Muhammad Zia,

Anna Csiszár,

Nazar Labinskyy,

Furong Hu,

Govindaiah Vinukonda,

Edmund F. LaGamma,

Zoltán Ungvári,

Praveen Ballabh

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.544759

Subject(s) - apocynin , medicine , oxidative stress , germinal matrix , intraventricular hemorrhage , anesthesia , nitrotyrosine , neuroprotection , nitric oxide , xanthine oxidase , allopurinol , xanthine oxidase inhibitor , endocrinology , pharmacology , nitric oxide synthase , biochemistry , nadph oxidase , chemistry , biology , pregnancy , genetics , enzyme , gestational age

Germinal matrix hemorrhage-intraventricular hemorrhage is the most common neurological problem of premature infants. Despite this, mechanisms of brain injury from intraventricular hemorrhage are elusive. We hypothesized that germinal matrix hemorrhage-intraventricular hemorrhage, by induction of NAD(P)H oxidases, might cause oxidative/nitrosative stress contributing to brain injuries and that NAD(P)H oxidase inhibition could offer neuroprotection.

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