Genetic Determinants of White Matter Hyperintensities on Brain Scans | Zendy

Lavinia Paternoster | Zendy; Wanting Chen | Zendy; Cathie Sudlow | Zendy

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Genetic Determinants of White Matter Hyperintensities on Brain Scans

Author(s) -

Lavinia Paternoster,

Wanting Chen,

Cathie Sudlow

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.542050

Subject(s) - medicine , hyperintensity , white matter , neuroimaging , stroke (engine) , leukoaraiosis , magnetic resonance imaging , neuroscience , radiology , psychiatry , mechanical engineering , engineering , biology

White matter hyperintensities (WMH) are highly heritable and associated with small artery ischemic stroke, so they may be a useful trait for studying the genetics of small vessel disease. Many studies have attempted to find associations between polymorphisms in various candidate genes and WMH. We aimed to evaluate the evidence for these associations by performing a systematic review and series of meta-analyses.

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