Inducible Nitric Oxide Synthase Promoter Polymorphism Affords Protection Against Cognitive Dysfunction After Carotid Endarterectomy | Zendy

Gene T. Yocum | Zendy; John G. Gaudet | Zendy; Susie S. Lee | Zendy; Yaakov Stern | Zendy; Lauren A. Teverbaugh | Zendy; Robert R. Sciacca | Zendy; Charles W. Emala | Zendy; Donald O. Quest | Zendy; Paul C. McCormick | Zendy; James F. McKinsey | Zendy; Nicholas J. Morrissey | Zendy; Robert A. Solomon | Zendy; E. Sander Connolly | Zendy; Éric Heyer | Zendy

Open Access

Inducible Nitric Oxide Synthase Promoter Polymorphism Affords Protection Against Cognitive Dysfunction After Carotid Endarterectomy

Author(s) -

Gene T. Yocum,

John G. Gaudet,

Susie S. Lee,

Yaakov Stern,

Lauren A. Teverbaugh,

Robert R. Sciacca,

Charles W. Emala,

Donald O. Quest,

Paul C. McCormick,

James F. McKinsey,

Nicholas J. Morrissey,

Robert A. Solomon,

E. Sander Connolly,

Éric Heyer

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.541177

Subject(s) - medicine , carotid endarterectomy , nitric oxide synthase , gastroenterology , asymptomatic , endarterectomy , cognitive decline , incidence (geometry) , surgery , pathology , nitric oxide , stenosis , disease , dementia , physics , optics

Cognitive dysfunction occurs in 9% to 23% of patients during the first month after carotid endarterectomy (CEA). A 4-basepair (AAAT) tandem repeat polymorphism (either 3 or 4 repeats) has been described in the promoter region of inducible nitric oxide synthase (iNOS), a gene with complex roles in ischemic injury and preconditioning against ischemic injury. We investigated whether the 4-repeat variant (iNOS(+)) affects the incidence of cognitive dysfunction after CEA.

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