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A noninvasive MRI method to measure cerebral oxygen metabolism has the potential to assess tissue viability during cerebral ischemia. The purposes of this study were to validate MR oxygenation measurements across a wide range of global cerebral oxygenation and to examine the spatiotemporal evolution of oxygen metabolism during focal middle cerebral artery occlusion in rats.

Evaluation of MR-Derived Cerebral Oxygen Metabolic Index in Experimental Hyperoxic Hypercapnia, Hypoxia, and Ischemia