Invasive Cortical Stimulation to Promote Recovery of Function After Stroke | Zendy

Ela B. Plow | Zendy; James R. Carey | Zendy; Randolph J. Nudo | Zendy; Álvaro PascualLeone | Zendy

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Invasive Cortical Stimulation to Promote Recovery of Function After Stroke

Author(s) -

Ela B. Plow,

James R. Carey,

Randolph J. Nudo,

Álvaro PascualLeone

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.540823

Subject(s) - medicine , stimulation , stroke (engine) , stroke recovery , neuroplasticity , brain stimulation , neuroscience , rehabilitation , physical medicine and rehabilitation , transcranial direct current stimulation , functional electrical stimulation , clinical trial , physical therapy , psychology , pathology , mechanical engineering , engineering

Residual motor deficits frequently linger after stroke. Search for newer effective strategies to promote functional recovery is ongoing. Brain stimulation, as a means of directing adaptive plasticity, is appealing. Animal studies and Phase I and II trials in humans have indicated safety, feasibility, and efficacy of combining rehabilitation and concurrent invasive cortical stimulation. However, a recent Phase III trial showed no advantage of the combination. We critically review results of various trials and discuss the factors that contributed to the distinctive result.

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