Treatment Time-Specific Number Needed to Treat Estimates for Tissue Plasminogen Activator Therapy in Acute Stroke Based on Shifts Over the Entire Range of the Modified Rankin Scale | Zendy

Maarten G. Lansberg | Zendy; Maarten Schrooten | Zendy; Erich Bluhmki | Zendy; Vincent Thijs | Zendy; Jeffrey L. Saver | Zendy

Open Access

Treatment Time-Specific Number Needed to Treat Estimates for Tissue Plasminogen Activator Therapy in Acute Stroke Based on Shifts Over the Entire Range of the Modified Rankin Scale

Author(s) -

Maarten G. Lansberg,

Maarten Schrooten,

Erich Bluhmki,

Vincent Thijs,

Jeffrey L. Saver

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.540708

Subject(s) - number needed to treat , medicine , number needed to harm , modified rankin scale , tissue plasminogen activator , randomized controlled trial , confidence interval , surgery , relative risk , ischemic stroke , ischemia

To make informed treatment decisions, patients and physicians need to be aware of the benefits and risks of a proposed treatment. The number needed to treat (NNT) for benefit and harm are intuitive and statistically valid measures to describe a treatment effect. The aim of this study is to calculate treatment time-specific NNT estimates based on shifts over the entire spectrum of clinically relevant functional outcomes.

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