Severe Cerebral White Matter Hyperintensities Predict Severe Cognitive Decline in Patients With Cerebrovascular Disease History | Zendy

Carole Dufouil | Zendy; O. Godin | Zendy; John Chalmers | Zendy; Oghuzan Coskun | Zendy; Stephen MacMahon | Zendy; Nathalie TzourioMazoyer | Zendy; MarieGermaine Bousser | Zendy; Craig S. Anderson | Zendy; Bernard Mazoyer | Zendy; Christophe Tzourio | Zendy

Open Access

Severe Cerebral White Matter Hyperintensities Predict Severe Cognitive Decline in Patients With Cerebrovascular Disease History

Author(s) -

Carole Dufouil,

O. Godin,

John Chalmers,

Oghuzan Coskun,

Stephen MacMahon,

Nathalie TzourioMazoyer,

MarieGermaine Bousser,

Craig S. Anderson,

Bernard Mazoyer,

Christophe Tzourio

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.540633

Subject(s) - medicine , hyperintensity , cognitive decline , white matter , disease , leukoaraiosis , stroke (engine) , cardiology , magnetic resonance imaging , dementia , radiology , mechanical engineering , engineering

Cerebral white matter hyperintensities (WMHs) are believed to be the consequence of small vessel disease, and it is uncertain whether their extent predicts the risk of dementia in patients with vascular disease history. Method- Brain MRI was performed in 226 participants of the PROGRESS study. WMH severity was assessed using a visual rating scale. During follow-up, patients were classified for incident severe cognitive deterioration (including dementia) using standard criteria.

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