Relative Importance of Proteinase-Activated Receptor-1 Versus Matrix Metalloproteinases in Intracerebral Hemorrhage-Mediated Neurotoxicity in Mice | Zendy

Mengzhou Xue | Zendy; Morley D. Hollenberg | Zendy; Andrew M. Demchuk | Zendy; V. Wee Yong | Zendy

Open Access

Relative Importance of Proteinase-Activated Receptor-1 Versus Matrix Metalloproteinases in Intracerebral Hemorrhage-Mediated Neurotoxicity in Mice

Author(s) -

Mengzhou Xue,

Morley D. Hollenberg,

Andrew M. Demchuk,

V. Wee Yong

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.540393

Subject(s) - intracerebral hemorrhage , thrombin , medicine , hirudin , neurotoxicity , matrix metalloproteinase , thrombin receptor , direct thrombin inhibitor , pharmacology , discovery and development of direct thrombin inhibitors , receptor , anesthesia , toxicity , platelet , dabigatran , subarachnoid hemorrhage , warfarin , atrial fibrillation

To reduce bleeding and damage to central nervous system tissue in intracerebral hemorrhage, the coagulant effect of thrombin is essential. However, thrombin itself can kill neurons in intracerebral hemorrhage as can the matrix metalloproteinases (MMPs), which are also elevated in this condition, in part due to thrombin-mediated activation of MMPs. It is thus important to understand and block the neurotoxic effects of thrombin without inhibiting its therapeutic outcomes. In this study, we have investigated the relative roles of proteinase activated receptor-1, a thrombin receptor, and MMPs in brain injury induced by thrombin or blood.

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