Placebo-Controlled Trial of High-Dose Atorvastatin in Patients With Severe Cerebral Small Vessel Disease | Zendy

Philippa C. Lavallée | Zendy; Julien Labreuche | Zendy; Fernando GóngoraRivera | Zendy; Arturo P Jaramillo | Zendy; David A. Brenner | Zendy; Isabelle Klein | Zendy; PierreJean Touboul | Zendy; Éric Vicaut | Zendy; Pierre Amarenco | Zendy

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Placebo-Controlled Trial of High-Dose Atorvastatin in Patients With Severe Cerebral Small Vessel Disease

Author(s) -

Philippa C. Lavallée,

Julien Labreuche,

Fernando GóngoraRivera,

Arturo P Jaramillo,

David A. Brenner,

Isabelle Klein,

PierreJean Touboul,

Éric Vicaut,

Pierre Amarenco

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.540088

Subject(s) - medicine , atorvastatin , placebo , brachial artery , cardiology , stroke (engine) , endothelial dysfunction , vascular disease , clinical endpoint , randomized controlled trial , blood pressure , pathology , mechanical engineering , alternative medicine , engineering

Uncontrolled studies have shown that statins can improve cerebral vasoreactivity (CVR) in patients with mild small vessel disease. We sought to determine whether high-dose atorvastatin increases CVR compared with placebo in patients with severe small vessel disease.

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