No Association of the Plasma Glutathione Peroxidase ( GPx-3 ) Gene With Cerebral Venous Thrombosis in the German Population | Zendy

Caspar GrondGinsbach | Zendy; Marie-Luise Arnold | Zendy; Christoph Lichy | Zendy; Armin Grau | Zendy; Karl Reuner | Zendy

Open Access

No Association of the Plasma Glutathione Peroxidase ( GPx-3 ) Gene With Cerebral Venous Thrombosis in the German Population

Author(s) -

Caspar GrondGinsbach,

Marie-Luise Arnold,

Christoph Lichy,

Armin Grau,

Karl Reuner

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.540062

Subject(s) - medicine , venous thrombosis , thrombosis , gpx3 , german , stroke (engine) , german population , glutathione peroxidase , vascular disease , population , cardiology , oxidative stress , mechanical engineering , catalase , environmental health , archaeology , engineering , history

To the Editor:In a recent publication in Stroke , cerebral venous thrombosis (CVT) was found to be associated with a variant of the plasma glutathione peroxidase ( GPx-3 ) gene (promoter haplotype H2).1 The observed association was strong (OR >10) and highly significant ( P <0.0001). However, the number of analyzed patients was small (n=23) and the findings were not confirmed in an independent study population. We analyzed 79 patients with nonseptic CVT and 203 healthy control subjects and sought to confirm the association between GPx-3 and CVT. Our study groups were characterized in detail elsewhere.2 We tagged haplotype H2 with SNP rs1946235 (this is …

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