Carotid Repair Using Autologous Adipose-Derived Endothelial Cells | Zendy

Harald Froehlich | Zendy; Rajiv Gulati | Zendy; Barry A. Boilson | Zendy; Tyra A. Witt | Zendy; Adriana Harbuzariu | Zendy; Laurel S. Kleppe | Zendy; Allan B. Dietz | Zendy; Amir Lerman | Zendy; Robert D. Simari | Zendy

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Carotid Repair Using Autologous Adipose-Derived Endothelial Cells

Author(s) -

Harald Froehlich,

Rajiv Gulati,

Barry A. Boilson,

Tyra A. Witt,

Adriana Harbuzariu,

Laurel S. Kleppe,

Allan B. Dietz,

Amir Lerman,

Robert D. Simari

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.539932

Subject(s) - medicine , progenitor cell , adipose tissue , population , stem cell , endothelium , pathology , microbiology and biotechnology , biology , environmental health

Adipose tissue is an abundant source of endothelial cells as well as stem and progenitor cells which can develop an endothelial phenotype. It has been demonstrated that these cells have distinct angiogenic properties in vitro and in vivo. However, whether these cells have the capacity to directly improve large vessel form and function after vascular injury remains unknown. To define whether delivery of adipose-derived endothelial cells (ADECs) would improve healing of injured carotid arteries, a rabbit model of acute arterial injury was used.

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