Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage: Is Angiographic Vasospasm an Epiphenomenon? | Zendy

Mervyn D.I. Vergouwen | Zendy; Marinus Vermeulen | Zendy; Yvo B.W.E.M. Roos | Zendy

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Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage: Is Angiographic Vasospasm an Epiphenomenon?

Author(s) -

Mervyn D.I. Vergouwen,

Marinus Vermeulen,

Yvo B.W.E.M. Roos

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.537985

Subject(s) - medicine , subarachnoid hemorrhage , epiphenomenon , vasospasm , ischemia , cardiology , cerebral vasospasm , anesthesia , philosophy , epistemology

To the Editor:We would like to congratulate the Clazosentan to Overcome Neurological Ischemia and Infarction Occurring After Subarachnoid Hemorrhage (CONSCIOUS-1) investigators with the completion of this large phase IIb study, investigating the effect of the endothelin receptor A antagonist clazosentan in patients with aneurysmal hemorrhage.1 We have a few comments.First, the CONSCIOUS-1 study has angiographic vasospasm as a primary end point. Although we understand this from a pathophysiological point of view, namely that angiographic vasospasm is caused by endothelin release and might be counteracted by an endothelin …

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