Candesartan Augments Ischemia-Induced Proangiogenic State and Results in Sustained Improvement After Stroke | Zendy

Anna Kozak | Zendy; Adviye Ergul | Zendy; Azza B. ElRemessy | Zendy; Maribeth H. Johnson | Zendy; Sandro Lemos Machado | Zendy; Hazem Elewa | Zendy; Mohammed Abdelsaid | Zendy; Daniel C. Wiley | Zendy; Susan C. Fagan | Zendy

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Candesartan Augments Ischemia-Induced Proangiogenic State and Results in Sustained Improvement After Stroke

Author(s) -

Anna Kozak,

Adviye Ergul,

Azza B. ElRemessy,

Maribeth H. Johnson,

Sandro Lemos Machado,

Hazem Elewa,

Mohammed Abdelsaid,

Daniel C. Wiley,

Susan C. Fagan

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.537225

Subject(s) - medicine , candesartan , ischemia , vascular endothelial growth factor , middle cerebral artery , occlusion , stroke (engine) , anesthesia , blood pressure , angiotensin ii , mechanical engineering , engineering , vegf receptors

We have shown that acute treatment with candesartan in an experimental model of stroke resulted in vascular protection and improved outcomes at 24 hours poststroke, but the mechanisms are unknown. We now examine effects of candesartan on proangiogenic factors and 7-day outcomes using the same treatment paradigm.

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