Degeneration of Astrocytic Processes and Their Mitochondria in Cerebral Cortical Regions Peripheral to the Cortical Infarction | Zendy

Umeo Ito | Zendy; Yoji Hakamata | Zendy; Emiko Kawakami | Zendy; Kiyomitsu Oyanagi | Zendy

Open Access

Degeneration of Astrocytic Processes and Their Mitochondria in Cerebral Cortical Regions Peripheral to the Cortical Infarction

Author(s) -

Umeo Ito,

Yoji Hakamata,

Emiko Kawakami,

Kiyomitsu Oyanagi

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.534990

Subject(s) - neuropil , medicine , cerebral cortex , astrocyte , neuron , mitochondrion , neuroscience , pathology , cortex (anatomy) , cortical neurons , anatomy , central nervous system , biology , microbiology and biotechnology

Astrocytes support neuronal functions by regulating the extracellular ion-homeostasis and levels of neurotransmitters, and by providing fuel such as lactate to the neurons via their astrocytic processes (APs). Whether injured APs are associated with neuronal survival/death is still an unanswered question. We investigated APs in the neuropil, especially those around astrocytes and normal-appearing, degenerating, and dead neurons in cerebral cortical regions peripheral to the cortical infarction (RPI).

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