VEGF Stimulates the ERK 1/2 Signaling Pathway and Apoptosis in Cerebral Endothelial Cells After Ischemic Conditions | Zendy

Purnima Narasimhan | Zendy; Jing Liu | Zendy; Yun Seon Song | Zendy; Justin Massengale | Zendy; Pak H. Chan | Zendy

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VEGF Stimulates the ERK 1/2 Signaling Pathway and Apoptosis in Cerebral Endothelial Cells After Ischemic Conditions

Author(s) -

Purnima Narasimhan,

Jing Liu,

Yun Seon Song,

Justin Massengale,

Pak H. Chan

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.534644

Subject(s) - medicine , apoptosis , mapk/erk pathway , signal transduction , microbiology and biotechnology , cancer research , genetics , biology

Cerebral endothelial cells that line microvessels play an important role in maintaining blood flow homeostasis within the brain-forming part of the blood-brain barrier. These cells are injured by hypoxia-induced reperfusion, leading to blood-brain barrier breakdown and exacerbation of ischemic injury. We investigated the roles of vascular endothelial growth factor (VEGF) and the downstream extracellular signal-regulated kinase (ERK) protein after oxygen-glucose deprivation (OGD) in primary endothelial cells.

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