Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke | Zendy

Mathias Gelderblom | Zendy; Frank Leypoldt | Zendy; Karin Steinbach | Zendy; D. Behrens | Zendy; Chiun Choe | Zendy; Dominic A. Siler | Zendy; Thiruma V. Arumugam | Zendy; Ellen Orthey | Zendy; Christian Gerloff | Zendy; Eva Tolosa | Zendy; Tim Magnus | Zendy

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Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

Author(s) -

Mathias Gelderblom,

Frank Leypoldt,

Karin Steinbach,

D. Behrens,

Chiun Choe,

Dominic A. Siler,

Thiruma V. Arumugam,

Ellen Orthey,

Christian Gerloff,

Eva Tolosa,

Tim Magnus

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.534503

Subject(s) - microglia , cd80 , immune system , medicine , cd8 , immunology , inflammation , downregulation and upregulation , major histocompatibility complex , infiltration (hvac) , antigen presenting cell , t cell , cytotoxic t cell , biology , cd40 , biochemistry , physics , gene , in vitro , thermodynamics

Ischemic stroke leads to significant morbidity and mortality in the Western world. Early reperfusion strategies remain the treatment of choice but can initiate and augment an inflammatory response causing secondary brain damage. The understanding of postischemic inflammation is very limited. The objectives of this study were to define the temporal and spatial infiltration of immune cell populations and their activation patterns in a murine cerebral ischemia-reperfusion injury model.

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