Cognition in CADASIL | Zendy

Martin Dichgans | Zendy

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Cognition in CADASIL

Author(s) -

Martin Dichgans

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.534412

Subject(s) - cadasil , medicine , dementia , vascular dementia , cognition , neuroimaging , randomized controlled trial , leukoencephalopathy , cognitive impairment , disease , neuroscience , stroke (engine) , psychiatry , psychology , mechanical engineering , engineering

CADASIL is an early onset small vessel disease and genetic variant of pure subcortical ischemic vascular dementia (SIVD). The condition has been invaluable in defining the profile and neuroimaging correlates of cognitive deficits in pure SIVD. The recent completion of a randomized trial in cognitively impaired CADASIL patients has illustrated the feasibility of targeted therapeutic trials in narrowly defined subtypes of vascular cognitive impairment. This article highlights some of the advances on cognition in CADASIL.

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