Mechanisms Underlying Improved Recovery of Neurological Function After Stroke in the Rodent After Treatment With Neurorestorative Cell-Based Therapies | Zendy

Michael Chopp | Zendy; Yi Li | Zendy; Zheng Gang Zhang | Zendy

Open Access

Mechanisms Underlying Improved Recovery of Neurological Function After Stroke in the Rodent After Treatment With Neurorestorative Cell-Based Therapies

Author(s) -

Michael Chopp,

Yi Li,

Zheng Gang Zhang

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.533141

Subject(s) - medicine , stroke (engine) , neuroscience , stroke recovery , white matter , neuroplasticity , endogeny , spinal cord , cell therapy , stem cell , physical therapy , rehabilitation , magnetic resonance imaging , mechanical engineering , genetics , radiology , psychiatry , engineering , biology

We discuss the mechanisms of action underlying the beneficial effects of treating ischemic stroke in the rodent with exogenously administered cells. The essential hypothesis proposed is that the administered cells enhance recovery of neurological function by stimulating the production of restorative factors by parenchymal cells. These activated endogenous brain cells evoke white matter remodeling in the brain and the spinal cord and generate microenvironments within the injured brain that amplify brain plasticity and lead to improvement in neurological function poststroke.

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