Therapeutic Potential and Possible Risks of Pleiotropic Growth Factors in Ischemic Stroke | Zendy

Dirk M. Hermann | Zendy; Ertuğrul Kılıç | Zendy

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Therapeutic Potential and Possible Risks of Pleiotropic Growth Factors in Ischemic Stroke

Author(s) -

Dirk M. Hermann,

Ertuğrul Kılıç

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.532374

Subject(s) - medicine , stroke (engine) , ischemic stroke , neurology , neuroprotection , inclusion and exclusion criteria , stroke recovery , ischemia , bioinformatics , physical therapy , pathology , alternative medicine , rehabilitation , psychiatry , mechanical engineering , engineering , biology

To the Editor:In their meta-analysis, Minnerup and collegues1 summarize work on granulocyte-colony stimulating factor (G-CSF) in rat and mouse models of focal cerebral ischemia, concluding that G-CSF based on its survival- and recovery-promoting effects in a total of 13 experimental stroke studies is a confident candidate for stroke treatment. Unlike other neuroprotectants, G-CSF appears to exhibit a particularly long time-window of opportunity, which makes this factor interesting for clinical application. …

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