Anoxia-Induced NF-kB-Dependent Upregulation of NCX1 Contributes to Ca 2+ Refilling Into Endoplasmic Reticulum in Cortical Neurons | Zendy

Rossana Sirabella | Zendy; Agnese Secondo | Zendy; Anna Pannaccione | Zendy; Antonella Scorziello | Zendy; Valeria Valsecchi | Zendy; Annagrazia Adornetto | Zendy; Leonilda Bilo | Zendy; Gianfranco Di Renzo | Zendy; Lucio Annunziato | Zendy

Open Access

Anoxia-Induced NF-kB-Dependent Upregulation of NCX1 Contributes to Ca ²⁺ Refilling Into Endoplasmic Reticulum in Cortical Neurons

Author(s) -

Rossana Sirabella,

Agnese Secondo,

Anna Pannaccione,

Antonella Scorziello,

Valeria Valsecchi,

Annagrazia Adornetto,

Leonilda Bilo,

Gianfranco Di Renzo,

Lucio Annunziato

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.531962

Subject(s) - downregulation and upregulation , endoplasmic reticulum , western blot , sodium calcium exchanger , cytosol , gene expression , microbiology and biotechnology , small interfering rna , medicine , endocrinology , biology , intracellular , transfection , biochemistry , gene , enzyme

The 3 gene products of the Na(+)/Ca(2+) exchanger (NCX), viz, NCX1, NCX2, and NCX3, may play a pivotal role in the pathophysiology of brain ischemia. The aim of this study was to investigate the transductional and posttranslational mechanisms involved in the expression of these isoforms during oxygen and glucose deprivation and their role in endoplasmic reticulum Ca(2+) refilling in cortical neurons.

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