Brain-Derived Neurotrophic Factor Contributes to Recovery of Skilled Reaching After Focal Ischemia in Rats | Zendy

Michelle Ploughman | Zendy; Victoria Windle | Zendy; Crystal L. MacLellan | Zendy; Nicole M. White | Zendy; Jules J.E. Doré | Zendy; Dale Corbett | Zendy

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Brain-Derived Neurotrophic Factor Contributes to Recovery of Skilled Reaching After Focal Ischemia in Rats

Author(s) -

Michelle Ploughman,

Victoria Windle,

Crystal L. MacLellan,

Nicole M. White,

Jules J.E. Doré,

Dale Corbett

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.531806

Subject(s) - neurotrophic factors , medicine , brain derived neurotrophic factor , neuroplasticity , rehabilitation , ischemia , stroke (engine) , neuroscience , forelimb , neurotrophin , physical medicine and rehabilitation , psychology , physical therapy , anatomy , receptor , psychiatry , mechanical engineering , engineering

Brain-derived neurotrophic factor (BDNF) is involved in neuronal survival, synaptic plasticity, learning and memory, and neuroplasticity. Further, exogenous treatment with BDNF or exposing animals to enrichment and exercise regimens, which also increase BDNF, enhances behavioral recovery after brain injury. Thus, the beneficial effects of rehabilitation in promoting recovery after stroke may also depend on BDNF. We tested this hypothesis by evaluating the contribution of BDNF to motor skill relearning after endothelin-1-induced middle cerebral artery occlusion in rats.

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