Using Historical Lesion Volume Data in the Design of a New Phase II Clinical Trial in Acute Stroke | Zendy

John Whitehead | Zendy; Kim Bolland | Zendy; Elsa ValdésMárquez | Zendy; Anela Lihic | Zendy; Myzoon Ali | Zendy; Kennedy R. Lees | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Using Historical Lesion Volume Data in the Design of a New Phase II Clinical Trial in Acute Stroke

Author(s) -

John Whitehead,

Kim Bolland,

Elsa ValdésMárquez,

Anela Lihic,

Myzoon Ali,

Kennedy R. Lees

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.531442

Subject(s) - medicine , sample size determination , lesion , placebo , odds ratio , clinical trial , stroke (engine) , magnetic resonance imaging , radiology , nuclear medicine , surgery , pathology , statistics , mechanical engineering , alternative medicine , mathematics , engineering

Clinical research into the treatment of acute stroke is complicated, is costly, and has often been unsuccessful. Developments in imaging technology based on computed tomography and magnetic resonance imaging scans offer opportunities for screening experimental therapies during phase II testing so as to deliver only the most promising interventions to phase III. We discuss the design and the appropriate sample size for phase II studies in stroke based on lesion volume.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research