Early-Stage Investigations of Ultrasmall Superparamagnetic Iron Oxide-Induced Signal Change After Permanent Middle Cerebral Artery Occlusion in Mice | Zendy

Virginie Desestret | Zendy; JeanChristophe Brisset | Zendy; S. Moucharrafie | Zendy; Emilie Devillard | Zendy; Serge Nataf | Zendy; Jérôme Honnorat | Zendy; Norbert Nighoghossian | Zendy; Yves Berthezène | Zendy; Marlène Wiart | Zendy

Open Access

Early-Stage Investigations of Ultrasmall Superparamagnetic Iron Oxide-Induced Signal Change After Permanent Middle Cerebral Artery Occlusion in Mice

Author(s) -

Virginie Desestret,

JeanChristophe Brisset,

S. Moucharrafie,

Emilie Devillard,

Serge Nataf,

Jérôme Honnorat,

Norbert Nighoghossian,

Yves Berthezène,

Marlène Wiart

Publication year - 2009

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.531269

Subject(s) - medicine , pathology , blood–brain barrier , cerebrospinal fluid , monocyte , middle cerebral artery , ischemia , central nervous system , immunology

MR signal changes after intravenous ultrasmall superparamagnetic iron oxide (USPIO) injection are related to inflammatory cells at the subacute stages after focal cerebral injury. However, at the early stages, the interpretation of USPIO-related MR signal alterations remains controversial. Here, we compared MR signal changes after intravenous USPIO injection with the histological iron and macrophage distribution during the first 24 hours in a rodent model of acute stroke.

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