Microarray RNA Expression Analysis of Cerebral White Matter Lesions Reveals Changes in Multiple Functional Pathways | Zendy

Julie E. Simpson | Zendy; Ola Hosny | Zendy; Stephen B. Wharton | Zendy; Paul R. Heath | Zendy; Hazel M. Holden | Zendy; Malee Fernando | Zendy; Fiona E. Matthews | Zendy; Gill Forster | Zendy; John T. O’Brien | Zendy; Robert Barber | Zendy; Raj N. Kalaria | Zendy; Carol Brayne | Zendy; Pamela J. Shaw | Zendy; Claire E. Lewis | Zendy; Paul G. Ince | Zendy

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Microarray RNA Expression Analysis of Cerebral White Matter Lesions Reveals Changes in Multiple Functional Pathways

Author(s) -

Julie E. Simpson,

Ola Hosny,

Stephen B. Wharton,

Paul R. Heath,

Hazel M. Holden,

Malee Fernando,

Fiona E. Matthews,

Gill Forster,

John T. O’Brien,

Robert Barber,

Raj N. Kalaria,

Carol Brayne,

Pamela J. Shaw,

Claire E. Lewis,

Paul G. Ince

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.529214

Subject(s) - microarray analysis techniques , microarray , white matter , medicine , gene expression , hyperintensity , rna , biological pathway , pathology , gene , biology , genetics , magnetic resonance imaging , radiology

White matter lesions (WML) in brain aging are linked to dementia and depression. Ischemia contributes to their pathogenesis but other mechanisms may contribute. We used RNA microarray analysis with functional pathway grouping as an unbiased approach to investigate evidence for additional pathogenetic mechanisms.

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