Leptin Is Induced in the Ischemic Cerebral Cortex and Exerts Neuroprotection Through NF-κB/c-Rel–Dependent Transcription | Zendy

Alessandra Valerio | Zendy; Marta Dossena | Zendy; P Bertolotti | Zendy; F. Boroni | Zendy; Ilenia Sarnico | Zendy; Giuseppe Faraco | Zendy; Alberto Chiarugi | Zendy; Andrea Frontini | Zendy; Antonio Giordano | Zendy; HsiouChi Liou | Zendy; Maria Grazia De Simoni | Zendy; PierFranco Spano | Zendy; Michele O. Carruba | Zendy; Marina Pizzi | Zendy; Enzo Nisoli | Zendy

Open Access

Leptin Is Induced in the Ischemic Cerebral Cortex and Exerts Neuroprotection Through NF-κB/c-Rel–Dependent Transcription

Author(s) -

Alessandra Valerio,

Marta Dossena,

P Bertolotti,

F. Boroni,

Ilenia Sarnico,

Giuseppe Faraco,

Alberto Chiarugi,

Andrea Frontini,

Antonio Giordano,

HsiouChi Liou,

Maria Grazia De Simoni,

PierFranco Spano,

Michele O. Carruba,

Marina Pizzi,

Enzo Nisoli

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.528588

Subject(s) - leptin , neuroprotection , medicine , endocrinology , middle cerebral artery , ischemia , obesity

Leptin is an adipose hormone endowed with angiopoietic, neurotrophic, and neuroprotective properties. We tested the hypothesis that leptin might act as an endogenous mediator of recovery after ischemic stroke and investigated whether nuclear transcription factors kappaB activation is involved in leptin-mediated neuroprotection.

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