Right-to-Left Shunt in CADASIL Patients: A Comorbidity Factor? | Zendy

Sara Mazzucco | Zendy; Gian Paolo Anzola | Zendy; Nicolo’ Rizzuto | Zendy

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Right-to-Left Shunt in CADASIL Patients: A Comorbidity Factor?

Author(s) -

Sara Mazzucco,

Gian Paolo Anzola,

Nicolo’ Rizzuto

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.527093

Subject(s) - cadasil , medicine , neurology , comorbidity , clinical neurology , pediatrics , leukoencephalopathy , psychiatry , psychology , neuroscience , disease

To the Editor:In 2001 Angeli et al1 reported a remarkably high prevalence of right to left shunt (RLS) in a single CADASIL pedigree, suggesting “a possible association between CADASIL and RLS”. Surprisingly, and notwithstanding the large volume of data building up on CADASIL pathogenesis and diagnosis, no further data has followed this first and only publication on this topic up to now. This is why we read with much interest the article from Zicari et al,2 reporting on a very high prevalence of RLS (71%) in a sample of 21 patients with CADASIL. However, some concerns have to be issued. …

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