Ordinal Reanalysis of the SHEP Trial | Zendy

Philip M. Bath | Zendy; Chamila Geeganage | Zendy; Laura J. Gray | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Ordinal Reanalysis of the SHEP Trial

Author(s) -

Philip M. Bath,

Chamila Geeganage,

Laura J. Gray

Publication year - 2008

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.108.527044

Subject(s) - medicine , stroke (engine) , gray (unit) , physical therapy , nuclear medicine , mechanical engineering , engineering

To the Editor:The article by Patel and colleagues relating to long-term follow-up of patients in the SHEP study1 highlights a common problem in vascular prevention trials, namely that the sample size needed to detect an effect on ‘all’ stroke (or the composite of stroke, myocardial infarction, and vascular death) is insufficient to assess effects on fatal events alone. In the case of SHEP, chlorthalidone-based antihypertensive therapy significantly reduced all stroke (269 events) but not fatal …

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research